Isseroff Lab - UC Davis
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News 86 Publications 11 Members

Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodyni...

Sa, Woller Sb, Ravula Fc, Tucci G, Beaton M, Corr Rivkah Isseroff Am, Soulika Marianne Chigbrow Ka, Eddinger Tl, Yaksh ...

Published in Brain Behavior and Immunity

Objective: Pain resulting from local tissue injury or inflammation typically resolves with time. Frequently, however, this pain may unexpectedly persist, becoming a pathological chronic state. Increasingly, the innate and adaptive immune systems are being implicated in the initiation and maintenance of these persistent conditions. In particular, To...

High fluence light emitting diode-generated red light modulates characteristics associated with skin fibrosis.

Andrew Mamalis E, Koo M, Garcha Wj, Murphy Rivkah Isseroff Jared Jagdeo

Published in Journal of Biophotonics

Skin fibrosis, often referred to as skin scarring, is a significant international health problem with limited treatment options. The hallmarks of skin fibrosis are increased fibroblast proliferation, collagen production, and migration speed. Recently published clinical observations indicate that visible red light may improve skin fibrosis. In this ...

A systematic review of low-level light therapy for treatment of diabetic foot ulcer. PDF available through Get Fulltext Research

Tchanque-Fossuo, Catherine N Ho, Derek Dahle, Sara E Koo, Eugene Li, Chin-Shang Isseroff, R Rivkah Jagdeo, Jared

Published in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Diabetes mellitus (DM) is a significant international health concern affecting more than 387 million individuals. A diabetic person has a 25% lifetime risk of developing a diabetic foot ulcer (DFU), leading to limb amputation in up to one in six DFU patients. Low-level light therapy (LLLT) uses low-power lasers or light-emitting diodes to alter cel...

Resveratrol Prevents High Fluence Red Light-Emitting Diode Reactive Oxygen Species-Mediated Photoinhibition of Human Ski...

Andrew Mamalis E, Koo Rivkah Isseroff W, Murphy Jared Jagdeo

Published in PLoS ONE

Background: Skin fibrosis is a significant medical problem that leads to a functional, aesthetic, and psychosocial impact on quality-of-life. Light-emitting diode-generated 633-nm red light (LED-RL) is part of the visible light spectrum that is not known to cause DNA damage and is considered a safe, non-invasive, inexpensive, and portable potential...

Does class attendance matter? Results from a second-year medical school dermatology cohort study.

Db, Eisen Cw, Schupp Rivkah Isseroff Oa, Ibrahimi L, Ledo Aw, Armstrong

Published in Current Topics in Medicinal Chemistry

Background: Little is known about the impacts of class attendance and learning preferences on academic performance in dermatology. Objectives: This study was designed to examine the effects of medical student class attendance and learning preferences on students' academic performance in an introductory dermatology course. Methods: A total of ...

Hypoxic preconditioning of mesenchymal stromal cells induces metabolic changes, enhances survival, and promotes cell ret...

Beegle, Julie Lakatos, Kinga Kalomoiris, Stefanos Stewart, Heather Isseroff, R Rivkah Nolta, Jan A Fierro, Fernando A

Published in Stem cells (Dayton, Ohio)

Mesenchymal stem cells/multipotent stromal cells (MSCs) are promising therapeutics for a variety of conditions. However, after transplantation, cell retention remains extremely challenging. Given that many hypoxic signals are transitory and that the therapeutic administration of MSCs is typically into tissues that are normally hypoxic, we studied t...

Utilizing custom-designed galvanotaxis chambers to study directional migration of prostate cells.

Hsin-Ya Yang Tina La Rivkah Isseroff

Published in Journal of Visualized Experiments

The physiological electric field serves specific biological functions, such as directing cell migration in embryo development, neuronal outgrowth and epithelial wound healing. Applying a direct current electric field to cultured cells in vitro induces directional cell migration, or galvanotaxis. The 2-dimensional galvanotaxis method we demonstrate ...

Recovery and Cultivation of Keratinocytes From Shipped Mouse Skin.

Hsin-Ya Yang Tina La Z, Gurenko P, Steenhuis W, Liu Rivkah Isseroff

Published in Journal of Cellular Physiology

Murine keratinocyte culture from neonatal skin is an important tool for studying the functional role of specific genes in epithelial biology. However, when the transgenic animal is only available in a geographically distant local, obtaining viable keratinocytes can be problematic. A method for transferring the isolated murine skin from collaboratin...

Acute wounding alters the beta2-adrenergic signaling and catecholamine synthetic pathways in keratinocytes. PDF available through Get Fulltext Research

Raja Sivamani B, Shi E, Griffiths Sm, Vu Ha, Lev-Tov S, Dahle Marianne Chigbrow Tina La C, Mashburn Thomas Peavy ...

Published in Journal of Investigative Dermatology

Keratinocyte migration is critical for wound re-epithelialization. Previous studies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte migration. Here, we investigated the keratinocyte catecholamine synthetic pathway in response to acute trauma. Cultured keratinocytes were scratch wounded and expression l...

Acute wounding alters the beta2-adrenergic signaling and catecholamine synthetic pathways in keratinocytes. PDF available through Get Fulltext Research

Sivamani, Raja K Shi, Biao Griffiths, Elizabeth Vu, Shirley M Lev-Tov, Hadar A Dahle, Sara Chigbrow, Marianne La, Thi Dinh Mashburn, Chelcy Peavy, Thomas R ...

Published in The Journal of investigative dermatology

Keratinocyte migration is critical for wound re-epithelialization. Previous studies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte migration. Here, we investigated the keratinocyte catecholamine synthetic pathway in response to acute trauma. Cultured keratinocytes were scratch wounded and expression l...

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