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News 86 Publications 11 Members

Epithelialization in Wound Healing: A Comprehensive Review.

Pastar, Irena Stojadinovic, Olivera Yin, Natalie C Ramirez, Horacio Nusbaum, Aron G Sawaya, Andrew Patel, Shailee B Khalid, Laiqua Isseroff, Rivkah R Tomic-Canic, Marjana ...

Published in Advances in wound care

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization. This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, ...

Multiple firm nodules and tender, indurated plaques.

J, Olazagasti As, Wang Rivkah Isseroff

Published in JAMA Dermatology

Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregula... PDF available through Get Fulltext Research

Kim, Min-Ho Gorouhi, Farzam Ramirez, Sandra Granick, Jennifer L Byrne, Barbara A Soulika, Athena M Simon, Scott I Isseroff, Rivkah R

Published in The Journal of investigative dermatology

Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined. Here we demonstrate that epinephrine alters the neutrophil (polymorphonuclear leukocyte (PMN))-dependent inflammatory response to a cutaneous wound....

Plant-based modulation of Toll-like receptors: an emerging therapeutic model.

Chahal, Dev S Sivamani, Raja K Isseroff, R Rivkah Dasu, Mohan R

Published in Phytotherapy research : PTR

Plant-based extracts present a large source of natural immune modulators, many of which have been used in traditional medicine for centuries. Recent research efforts have identified plant extracts as potential modulators of Toll-like receptors (TLRs), the first responders in immunological defenses in normal and disease conditions. This review aims ...

The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes.

Hsin-Ya Yang Rp, Charles E, Hummler Dl, Baines Rivkah Isseroff

Published in Journal of Cell Science

Cellular directional migration in an electric field (galvanotaxis) is one of the mechanisms guiding cell movement in embryogenesis and in skin epidermal repair. The epithelial sodium channel (ENaC), in addition to its function of regulating sodium transport in kidney, has recently been found to modulate cell locomotory speed. Here we tested whether...

Cellular versus acellular matrix devices in treatment of diabetic foot ulcers: study protocol for a comparative efficacy...

Lev-Tov, H Li, C Dahle, S Rivkah Isseroff

Published in Trials

Electrical Stimulation Therapy and Wound Healing: Where Are We Now?

Rivkah Isseroff Se, Dahle

Published in Advances in Wound Care

Background Healing chronic wounds is an ongoing challenge for clinicians and poses a serious public health burden. Electrical stimulation (ES), broadly defined as the application of electrical current via electrodes placed on the skin adjacent to or directly within the wound, has been proposed as a therapeutic modality over a century ago, and rece...

Toll-like receptors in wound healing: location, accessibility, and timing. PDF available through Get Fulltext Research

Mr, Dasu Rivkah Isseroff

Published in Journal of Investigative Dermatology

Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs expression pattern, cellular localization, signaling, and deployment of inflammat...

Electrical Stimulation Therapy and Wound Healing: Where Are We Now? Adv Wound Care

Rivkah Isseroff Dahle, S

Toll-like receptors and diabetes: a therapeutic perspective

Dasu, M R Ramirez, S Rivkah Isseroff

Published in Clin Sci (Lond)

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