Mr, Dasu Rivkah Isseroff
Published in
Journal of Investigative Dermatology
Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs expression pattern, cellular localization, signaling, and deployment of inflammat...
Kim, Min-Ho Gorouhi, Farzam Ramirez, Sandra Granick, Jennifer L Byrne, Barbara A Soulika, Athena M Simon, Scott I Isseroff, Rivkah R
Published in
The Journal of investigative dermatology
Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined. Here we demonstrate that epinephrine alters the neutrophil (polymorphonuclear leukocyte (PMN))-dependent inflammatory response to a cutaneous wound....
Raja Sivamani B, Shi E, Griffiths Sm, Vu Ha, Lev-Tov S, Dahle Marianne Chigbrow Tina La C, Mashburn Thomas Peavy
...
Published in
Journal of Investigative Dermatology
Keratinocyte migration is critical for wound re-epithelialization. Previous studies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte migration. Here, we investigated the keratinocyte catecholamine synthetic pathway in response to acute trauma. Cultured keratinocytes were scratch wounded and expression l...
Sivamani, Raja K Shi, Biao Griffiths, Elizabeth Vu, Shirley M Lev-Tov, Hadar A Dahle, Sara Chigbrow, Marianne La, Thi Dinh Mashburn, Chelcy Peavy, Thomas R
...
Published in
The Journal of investigative dermatology
Keratinocyte migration is critical for wound re-epithelialization. Previous studies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte migration. Here, we investigated the keratinocyte catecholamine synthetic pathway in response to acute trauma. Cultured keratinocytes were scratch wounded and expression l...
