Isseroff Lab - UC Davis

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Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregula... PDF available through Get Fulltext Research

Kim, Min-Ho Gorouhi, Farzam Ramirez, Sandra Granick, Jennifer L Byrne, Barbara A Soulika, Athena M Simon, Scott I Isseroff, Rivkah R

Published in The Journal of investigative dermatology

Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined. Here we demonstrate that epinephrine alters the neutrophil (polymorphonuclear leukocyte (PMN))-dependent inflammatory response to a cutaneous wound....

Acute wounding alters the beta2-adrenergic signaling and catecholamine synthetic pathways in keratinocytes. PDF available through Get Fulltext Research

Sivamani, Raja K Shi, Biao Griffiths, Elizabeth Vu, Shirley M Lev-Tov, Hadar A Dahle, Sara Chigbrow, Marianne La, Thi Dinh Mashburn, Chelcy Peavy, Thomas R ...

Published in The Journal of investigative dermatology

Keratinocyte migration is critical for wound re-epithelialization. Previous studies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte migration. Here, we investigated the keratinocyte catecholamine synthetic pathway in response to acute trauma. Cultured keratinocytes were scratch wounded and expression l...

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